DHEA declines ~2-4% annually from age 30, reaching only 5-10% of peak levels by age 80. Low DHEA predicts cardiovascular disease (2.3× higher risk), bone loss, and cognitive decline; supplementation at 25-50 mg/day restores tissue-specific androgen/estrogen signaling.

DHEA 25-50 mg daily increases bone mineral density (+1.6% lumbar spine), improves sexual desire and arousal (65% vs. 36% placebo), and reduces depressive symptoms (47% vs. 23% placebo) in postmenopausal women via tissue-specific androgen conversion.

Black cohosh and isoflavone genistein reduce hot flash frequency by 25-40% and 20% respectively through serotonergic modulation and selective estrogen receptor activation, with evidence supporting efficacy within 2-4 weeks.

Ashwagandha KSM-66, red maca, and vitamin B6 target mood, sleep, and energy in menopause through HPA axis modulation and neurotransmitter synthesis, with clinical evidence supporting ~25% cortisol reduction.

La menopausia no son solo sofocos: humor, sueño y energía también caen. Evidencia clínica de ashwagandha KSM-66, red maca peruana y vitamina B6 en la transición menopáusica.

Fisiología de los sofocos, evidencia clínica de black cohosh, isoflavonas de trébol rojo y genisteína, y por qué la combinación tiene lógica científica más allá de la moda.